TUBERCULOSIS

TUBERCULOSIS(Phthisis/Consumption/Koch’s)

CA; Mycobacterium tuberculosis

                                    hominis

                                    bovine

                                    avis

MOT: droplet

Tubercle – lesions – hardening – calcification - necrosis

PRIMARY COMPLEX: non-contagious because children swallow phlegm

S/sx:

F Afternoon fever

F night sweat

F fatigability

F Back pain,

F Chest pain

	ANTI-TB DRUGS
R	Rifampicin   (Rifadine/Rimactane)	600mg once a day	·Empty stomach ·Body fluid discoloration ·Hepatotoxic   (metabolism) ·Nephrotoxic   (elimination) ·Permanent discoloration of contact lenses
I	Isoniazid (Laniazid)	300 mg once a day	·Empty stomach ·Peripheral neuropathy ·Avoid alcohol ·Hepatotoxic ·Nephrotoxic
P	Pyrazinamide(Zinamide)	500 mg/tablet	·Before meals ·Monitor s/sx of liver impairment                         anorexia                         fatigue                         dark urine                         photosensitivity Liver function studies
E	Ethambutol (Myambutol)	1.5mg/kg once a day	·Not affected by food ·Report visual disturbances ·Hepatotoxic Not recommended for children
S	Streptomycin	1 g/day	·After meals ·Report Oliguria – nephrotoxic ·Ototoxic Neurotoxic